The test identifies the presence of the FGF4 retrogene insertion on chromosome 12. This mutation is one cause of shortened legs (CDDY, disproportional dwarfism) in dogs. It is also a risk factor for the occurrence of Hansen type 1 disc herniation (IVDD type 1). Leg length will differ depending on if the dog has one or two copies of the mutation as the mutation is incomplete...

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application of the test:
- Identification of heterozygous, healthy carriers for breeding selection.
- Differential diagnosis of weakness of the backhand
The test determines whether the mutation in the DNM1 gene is present, which has been described as a risk factor for the occurrence of 'Exercise Induced...

Application:
- Determination of the predisposition status for mating planning
- Differential diagnosis of muscle weakness, muscle wasting
The DMD:c.531-2A>G mutation in the DMD gene of the X chromosome of dogs is the causative factor for GRMD (X-linked Golden Retriever Muscular Dystrophy). The test investigates whether the mutation is present. The mode of inheritance is...

Application: - Identification of heterozygous carriers for breeding selection.
- Diagnosis in case of clinical symptoms
The mutation for OI, osteogenesis imperfecta, is located in the SERPHIN1 gene. Affected animals have a disturbed collagen formation, so that bones break easily (glass bones) and heal badly. The abnormalities start at 3 weeks with pain, lameness and bone...

Application:
- Identification of heterozygous carriers
- Differential diagnosis of growth disorders
The mutation in the gene COL11A2 investigated here leads to Skeletal Dysplasia 2 (SD2) in Labradors in the homozygous state. This is a mild form of disproportionate dwarfism. An affected dog may develop the typical phenotype of shortened legs with otherwise normal body size....