Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

ACAN-dwarfism is found in Shetland ponies and miniature horses, in which abnormal cartilage growth leading to skeletal problems and dwarfism. Four different disease-causing variants of the ACAN gene are known so far: d1, d2, d3* and d4. The inheritance is autosomal recessive.

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

The test identifies the presence of the FGF4 retrogene insertion on chromosome 12. This mutation is one cause of shortened legs (CDDY, disproportional dwarfism) in dogs. It is also a risk factor for the occurrence of Hansen type 1 disc herniation (IVDD type 1). Leg length will differ depending on if the dog has one or two copies of the mutation as the mutation is incomplete...

The hereditary disease, whose causative mutation in the MYO5A gene is detected with the test, was initially called Griscelli type 1 analogue syndrome because of the analogy in humans. In dogs, the term 'Colour Dilution Neuropathy' (CDN) has become common as well.
The mode of inheritance is autosomal recessive. If homozygous, living but non-viable puppies are born....

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

Cerebellar Abiotrophy is an autosomal recessive disease where affected animals develop ataxia due to the progressive death of brain cells responsible for movement. It is found in Arabians and related breeds.

Application: - Heterozygous carrier identification - Differential diagnosis in cases of locomotion and coordination problems
DWLM is a hypoplasia of the cerebellum that results in ataxia with varying severity from staggering gait to episodic falling. First symptoms appear when the dog starts to walk. It is in an autosomal recessively inherited disease, only dogs with two...

Horses with one or two copies of the Champagne mutation will have diluted coat color, including mane and tail. Classic Champagne (black base color), Gold Champagne (chestnut base color), Amber Champagne (bay base color) are possible.

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application:
- Identification of heterozygous carriers in breeding selection.
- Differential diagnosis of eye disorders.
Collie eye anomaly (CEA) is a developmental disorder of the eye characterised by hypoplasia (underdevelopment) of the choroid. In severe cases CEA leads to blindness. The disease occurs in...

Application:
- Identification of heterozygous carriers
The test examines the mutation in the RPGRIP1 gene, which is a risk factor for cone-rod dystrophy 4-progressive retinal atrophy (crd4/cord1-PRA) in longhaired miniature dachshunds.This is a complex disease in which other gene mutations also play an important role in disease progression.