The hereditary disease, whose causative mutation in the MYO5A gene is detected with the test, was initially called Griscelli type 1 analogue syndrome because of the analogy in humans. In dogs, the term 'Colour Dilution Neuropathy' (CDN) has become common as well.
The mode of inheritance is autosomal recessive. If homozygous, living but non-viable puppies are born....

Application: - Heterozygous carrier identification - Differential diagnosis in cases of locomotion and coordination problems
DWLM is a hypoplasia of the cerebellum that results in ataxia with varying severity from staggering gait to episodic falling. First symptoms appear when the dog starts to walk. It is in an autosomal recessively inherited disease, only dogs with two...

Application:
- Identification of heterozygous carriers
- Differential diagnosis in case of epileptic seizures
The test examines whether the dog carries the mutation c564_567delAGAC in the gene DIRAS1. According to current scientific knowledge, this is the cause of generalised myoclonic epilepsy in the Rhodesian Ridgeback. The mode of inheritance is monogenic autosomal...

Application: - Identification of heterozyous carriers. This test is used to determine whether the dog carries the mutation in the HCRTR2 gene that has been found to cause narcolepsy in Doberman Pinschers. The most striking feature of this disease is the triggering of cataplexy by excitatory events. This leads to flaccid paralysis of individual muscle groups (partial...

Application: - Identification of heterozygous carriers. This test is used to determine whether the dog carries the mutation in the HCRTR2 gene that has been found to cause narcolepsy in dachshunds. The most striking feature of this disease is the triggering of cataplexy by excitatory events. This leads to flaccid paralysis of individual muscle groups (partial paralysis), or...

Application: - Identification of heterozyous carriers. This test is used to determine whether the dog carries the mutation in the HCRTR2 gene that has been found to cause narcolepsy in Labrador Retrievers. The most striking feature of this disease is the triggering of cataplexy by excitatory events. This leads to flaccid paralysis of individual muscle groups (partial...

Application: - Identification of heterozygous carrier animals.
- Differential diagnosis of diseases of the central nervous system
The test examines whether the PPT1:c.736_737insC mutation is present in the PPT1 gene, which has been identified as the cause of NCL1 disease in dwarf dachshunds. NCL1 (neuronal ceroidipofuscinase 1) is a disease of the central nervous system....

Application: - Identification of heterozygous carrier animals. - Differential diagnosis of diseases of the central nervous system.
The test examines whether the c.325delC mutation, which has been identified as the cause of NCL2 disease, is present in the TTP1 gene. NCL2 (neuronal ceroidipofuscinase 2) is a disease of the central nervous system. Affected animals show...

Application: - Identification of heterozygous carrier animals. - Differential diagnosis of diseases of the central nervous system.
This test investigates whether the dog carries the CLN5:c.934_935delA' mutation, which has been identified as the cause of neuronal ceroid lipofuscinosis 5 (NCL5) in the Golden Retriever. NCL is a neurodegenerative disease of the central nervous...

The test examines whether the mutation MECR:c.823A>G resulting in Polioencephalopathy (PE) in Eurasier dogs is present in the MECR gene of the dog. Applications: - Identification of healthy, heterozygous carriers - Differential diagnostics for movement disorders in puppies