The test identifies the presence of the FGF4 retrogene insertion on chromosome 12. This mutation is one cause of shortened legs (CDDY, disproportional dwarfism) in dogs. It is also a risk factor for the occurrence of Hansen type 1 disc herniation (IVDD type 1). Leg length will differ depending on if the dog has one or two copies of the mutation as the mutation is incomplete...

The hereditary disease, whose causative mutation in the MYO5A gene is detected with the test, was initially called Griscelli type 1 analogue syndrome because of the analogy in humans. In dogs, the term 'Colour Dilution Neuropathy' (CDN) has become common as well.
The mode of inheritance is autosomal recessive. If homozygous, living but non-viable puppies are born....

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

Application: - Heterozygous carrier identification - Differential diagnosis in cases of locomotion and coordination problems
DWLM is a hypoplasia of the cerebellum that results in ataxia with varying severity from staggering gait to episodic falling. First symptoms appear when the dog starts to walk. It is in an autosomal recessively inherited disease, only dogs with two...

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application:
- Identification of heterozygous carriers in breeding selection.
- Differential diagnosis of eye disorders.
Collie eye anomaly (CEA) is a developmental disorder of the eye characterised by hypoplasia (underdevelopment) of the choroid. In severe cases CEA leads to blindness. The disease occurs in...

Application:
- Identification of heterozygous carriers
The test examines the mutation in the RPGRIP1 gene, which is a risk factor for cone-rod dystrophy 4-progressive retinal atrophy (crd4/cord1-PRA) in longhaired miniature dachshunds.This is a complex disease in which other gene mutations also play an important role in disease progression.

Test indication: a) Identfication of carriers among offsping of a carrier x free mating. b) Differential diagnosis of clinical PRA cases.
crd-PRA is an early onset type of PRA described for wirehaired dachshunds. The defect occurs in the NPHP4 gene and has an autosomal-recessive mode of inheritance.

Application:
- Differential diagnosis in case of clinical symptoms
- Detection of carriers that appear healthy
The CysII-B test identifies the mutation that causes Cystinuria in Miniature Pinschers. The mutation effect is autosomal dominant, but clinical symptoms can be very mild with dogs appearing healthy.

Application:
- Identification of clinically normal, heterozygous carriers. - Differential diagnosis in cases of manifest cystinuria.
The mutation investigated is responsible for cystinuria type I-A (CysI-A) in Newfoundland and Landseer dogs. The mode of inheritance is autosomal recessive.

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

Application:
- Identification of heterozygous carriers in breeding selection.
This test detects the mutation in the PKP1 gene which is responsible for Ectodermal dysplasia / Skin Fragility Syndrome in Chesapeake Bay Retrievers. 'ED' is an autosomal recessive skin disease in which affected puppies have extremely thin and fragile skin that peels off even when touched lightly....

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application of the test:
- Identification of heterozygous, healthy carriers for breeding selection.
- Differential diagnosis of weakness of the backhand
The test determines whether the mutation in the DNM1 gene is present, which has been described as a risk factor for the occurrence of 'Exercise Induced...