The package bundles DNA tests on hereditary diseases of the breed 'Golden Retriever':
GR-PRA1, GR-PRA2, GRMD, NCL5

The package bundles tests for hereditary diseases that may be important for the breed 'Golden Retriever'.
- GR-PRA1
- GR-PRA2
- ICT-A***
*** = partner laboratory (NOTE: app. 4-5 weeks turn-around-time)

This test investigates if the dog carries the mutation in the BEST1 gene that has been described as cause for the disease Canine Multifocal Retinopathy 1 (cmr1) in mastiff-related breeds.The disease is inherited as an autosomal recessive characteristic and only occurs if the dog carries two mutated alleles.

Cone-Rod Dystrophy 1, also known as crd1, is a disease in which the cone and rod cells in the retina degenerate, leading to blindness. Clinical signs can be seen as early as 11 weeks of age, and full blindness results in early adulthood.

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application:
- Determination of the predisposition status for mating planning
- Differential diagnosis of muscle weakness, muscle wasting
The DMD:c.531-2A>G mutation in the DMD gene of the X chromosome of dogs is the causative factor for GRMD (X-linked Golden Retriever Muscular Dystrophy). The test investigates whether the mutation is present. The mode of inheritance is...

Application: - Carrier identification - Differential diagnosis in clinical PRA.
With this test we investigate if the dog carries a mutation in the SLC4A3-gene that was identified as the cause of GR_PRA1. PRA (Progressive Retinal Atrophy) is the name for a group of diseases of the eye. They are characterised by a progressive degeneration of the retina that eventually leads...

Application: - Carrier identification - Differential diagnosis in clinical PRA.
With this test we investigate if the dog carries a mutation in the TTC8-gene that was identified as the cause of GR_PRA2. PRA (Progressive Retinal Atrophy) is the name for a group of diseases of the eye. They are characterised by a progressive degeneration of the retina that eventually leads to...

In Golden Retrievers, the mutation studied is thought to play a role in the development of scales of varying severity. *** = the test is carried out in a partner laboratory.
Please note: The processing time is up to 4-6 weeks due to the Corona pandemic.

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.