The package bundles DNA tests on hereditary diseases of the breed 'Golden Retriever':
GR-PRA1, GR-PRA2, GRMD, NCL5

The test detects the mutation (c.643_644dup) in the EFNB3 gene that causes Congenital Mirror Movement Disorder 1 (CMM1). The inheritance is autosomal recessive, meaning that only animals carrying two copies of the mutated gene will be affected. Affected dogs can exhibit varying degrees of limb paralysis and a characteristic gait characterized by synchronous movements of both...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This SNP marker-based DNA profile identity has the same objective as the previously used STR-based ID profiles: - Ensuring identity,
- proof of origin - Basis for parentage assessments
At Generatio, the SNP ID profiles are based on a chip analysis; you will receive the result as a PDF as well as for downloading in the online animal record
PLEASE NOTE: 1: This Test is not...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)
Please note: This DNA profile is not a breed determination.

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application:
- Determination of the predisposition status for mating planning
- Differential diagnosis of muscle weakness, muscle wasting
The DMD:c.531-2A>G mutation in the DMD gene of the X chromosome of dogs is the causative factor for GRMD (X-linked Golden Retriever Muscular Dystrophy). The test investigates whether the mutation is present. The mode of inheritance is...

Application: - Carrier identification - Differential diagnosis in clinical PRA.
With this test we investigate if the dog carries a mutation in the SLC4A3-gene that was identified as the cause of GR_PRA1. PRA (Progressive Retinal Atrophy) is the name for a group of diseases of the eye. They are characterised by a progressive degeneration of the retina that eventually leads...

Application: - Carrier identification - Differential diagnosis in clinical PRA.
With this test we investigate if the dog carries a mutation in the TTC8-gene that was identified as the cause of GR_PRA2. PRA (Progressive Retinal Atrophy) is the name for a group of diseases of the eye. They are characterised by a progressive degeneration of the retina that eventually leads to...

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.

Application: - Identification of carriers of the MDR1 (ABCB1) variant prior to medication use - Breeding planning to prevent the transmission of the mutation In dogs with a homozygous ABCB1/MDR1 gene defect, there is an increased uptake of certain drugs into the central nervous system. This results in severe poisoning at normal dosage. Affected drugs include ivermectin,...

Application: - Identification of heterozygous carrier animals. - Differential diagnosis of diseases of the central nervous system.
This test investigates whether the dog carries the CLN5:c.934_935delA' mutation, which has been identified as the cause of neuronal ceroid lipofuscinosis 5 (NCL5) in the Golden Retriever. NCL is a neurodegenerative disease of the central nervous...