Von-Willebrand-Disease Type 1

Application:
- Identification of heterozygous carriers
- Differential diagnosis of coagulation disorders
Von Willebrand disease (vWD) type 1 is due to a reduction of the blood clotting factor of the same name, caused by a mutation in exon 43. The mode of inheritance is autosomal recessive, only dogs with two defective genes are affected. The effect manifests itself in varying intensity depending on the need for clotting factor.