The package includes a selection of tests on coat colors and coat characteristics that can play a role in the breeding selection of dachshunds of all varieties. (Merle, S-Lokus, A-Lokus)

The bundle comprises a selection of tests on coat colors and coat characteristics that can play a role in the breeding selection of dachshunds of all varieties. (Merle, Haarlänge, Furnishing)

The package covers the tests for A-locus, B-locus and hair length, which might play a role in the breeding selection of dachshunds/dachshunds of all varieties with regard to coat expression

Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

This test investigates if the dog carries the mutation in the BEST1 gene that has been described as cause for the disease Canine Multifocal Retinopathy 1 (cmr1) in mastiff-related breeds.The disease is inherited as an autosomal recessive characteristic and only occurs if the dog carries two mutated alleles.

The test identifies the presence of the FGF4 retrogene insertion on chromosome 12. This mutation is one cause of shortened legs (CDDY, disproportional dwarfism) in dogs. It is also a risk factor for the occurrence of Hansen type 1 disc herniation (IVDD type 1). Leg length will differ depending on if the dog has one or two copies of the mutation as the mutation is incomplete...

Cone-Rod Dystrophy 1, also known as crd1, is a disease in which the cone and rod cells in the retina degenerate, leading to blindness. Clinical signs can be seen as early as 11 weeks of age, and full blindness results in early adulthood.

Application:
- Identification of heterozygous carriers
The test examines the mutation in the RPGRIP1 gene, which is a risk factor for cone-rod dystrophy 4-progressive retinal atrophy (crd4/cord1-PRA) in longhaired miniature dachshunds.This is a complex disease in which other gene mutations also play an important role in disease progression.

Test indication: a) Identfication of carriers among offsping of a carrier x free mating. b) Differential diagnosis of clinical PRA cases.
crd-PRA is an early onset type of PRA described for wirehaired dachshunds. The defect occurs in the NPHP4 gene and has an autosomal-recessive mode of inheritance.

Application: Identification of carriers for straight coat.
In most dog breeds curly hair is caused by a mutation in the KRT71 gene. A single defect is sufficient representing a dominant autosomal mode of inheritance. This mode allows for carriers with hidden non-curly alleles. Mating of a carrier dam with a carrier sire will result in 25% non-curly offspring. Long hair...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...