Combo package for the two base colors of horse coat coloring (Agouti, Extension).

Application: - Clarification of underlying causes in horses symptomatic for Exertional Myopathy - Pre-purchase examination: assessment of the risk of developing Exertional Myopathy type MIM due to genetic predisposition. - Mating planning. The test contains the 6 gene variants P2, P3, P4, P8, Px, K1, which are important genetic predispositions for the development of MIM =...

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

In the course of this examination, Generatio establishes the SNP markers, which, as DNA fingerprints, ensure the identity of a horse and, when compared in parentage assessments, show whether a parentage statement is correct. As a result, you will receive a DNA identity card in PDF format for each animal. To use SNP ID profiles in parentage assessments, all animals involved...

Turner syndrome is the most common chromosomal abnormality in mares.
The missing X chromosome leads to an incomplete internal reproductive tract with a normal exterior phenotype.
Application of the test:
- Differential diagnosis of infertility, inactive ovaries and underdeveloped fallopian tubes
- Ensuring normal X-chromosomal constitution in mares that are not jet sexually...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

Application:
- Identification of carriers in breeding selection
- Differential diagnosis in clinical cases of Exertional Myopathy.
PSSM1 is a form of Exertional Myopathy in which a disorder of the sugar metabolism of the muscles causes muscle damage.
The test detects the mutation (c.926G>A) in the GYS1 gene which causes PSSM1. The inheritance is incomplete autosomal...

Splashed White 1 (SW1) is a variant found in many different breeds. It is autosomal semi-dominant, so horses with two copies (SW1/SW1) have a more extreme phenotype than those with only one copy (n/SW1). Horses with one copy usually have a wide blaze, often wider on the lower part of the face. The face-white may be associated with blue eyes, white stockings and small white...

WFFS is a connective tissue disorder leading to the spontaneous abortion of the fetus or death/humane euthanasia of the foal. The disease is autosomal recessive and the mutation has been found in many breeds including: Warmbloods and related breeds, Riding ponies,Thoroughbreds, Haflingers, Quarter Horses, Paint Horses, and Appaloosas.
*** = the test is carried out in a...

The White Spotting W20 variant is found in many breeds. By itself it has very little influence on white patterning; instead, W20 acts as a “booster”: in combination with other “W” mutations, it can greatly increase the amount of white on a horse. It can also boost the amount of white in non-“W” patterns: (eg. Sabino-1, Tobiano, occasionally Frame Overo (when 2 copies are...

The test determines the genome-based values for individual inbreeding and diversity values. Applications: - Clarification of an individual's inbreeding status in cases of unspecified general health issues. - Development of a genome-based mating planning scheme for the preservation or improvement of genetic diversity in a breeding population. Generatio determines all 3...