Combo package for the two base colors of horse coat coloring (Agouti, Extension).

Application: - Clarification of underlying causes in symptomatic horses - Predisposition assessment in the context of a pre-purchase examination - Mating planning. The MIM-6 variant test replaces the name 'PSSM2 test' to reflect the effects of the tested variants and their significance for exertional myopathies. The test still contains the 6 gene variants P2, P3, P4, P8, Px,...

You will receive the results of the MIM-6 Var.-Test within 5 working days from the time the sample is accepted in the laboratory. Please note the guidelines below when ordering: - Please do not order a separate sampling set , instead please follow our instructions for hair sample collection: Link . - Send the sample to: Generatio GmbH - Center for Animal Genetics |...

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

The test detects the mutation in the STX17 gene (a 4.6 kb intronic duplication) which is causative for the Grey coat color. It is also a risk factor for melanoma. The inheritance is autosomal dominant. Horses with one or two copies of the genetic variant (n/G or G/G) will grey with time. This test detects if a horse has one or two copies of the Grey mutation.

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

PSSM1 is a form of exercise intolerance in which a disorder of the sugar metabolism of the muscles causes muscle damage.
The test detects the mutation (c.926G>A) in the GYS1 gene which causes PSSM1. The inheritance is incomplete autosomal dominant. Horses with one or two copies of the genetic variant (n/P1 or P1/P1) are at risk to develop symptoms of PSSM1; those with two...

Splashed White 1 (SW1) is a variant found in many different breeds. It is autosomal semi-dominant, so horses with two copies (SW1/SW1) have a more extreme phenotype than those with only one copy (n/SW1). Horses with one copy usually have a wide blaze, often wider on the lower part of the face. The face-white may be associated with blue eyes, white stockings and small white...

The test determines if the MITF mutation (EquCab3: Chr16:21567245_21567249delGTGTCT) which causes the Splashed White 3 (SW3) phenotype is present. The inheritance is autosomal semi-dominant. SW3 originated in the Quarter Horse "TD Kid".

The test determines if the PAX3 mutation (EquCab3: Chr6:11199140G>C) which causes the Splashed White 4 (SW4) phenotype is present. The inheritance is autosomal semi-dominant. SW4 originated in the Appaloosa Horse "I'za Last Jet".

WFFS is a connective tissue disorder leading to the spontaneous abortion of the fetus or death/humane euthanasia of the foal. The disease is autosomal recessive and the mutation has been found in many breeds including: Warmbloods and related breeds, Riding ponies,Thoroughbreds, Haflingers, Quarter Horses, Paint Horses, and Appaloosas.