Combo package for the two base colors of horse coat coloring (Agouti, Extension).

MIM - 6 Variant is the new name for the test that was previously offered as the PSSM2 test. The adaptation reflects the current findings in the field of exertional myopathies. The tests comprises the 6 gene variants (P2, P3, P4, P8, Px,K1) that are important genetic predispositions for the development of MIM (Muscle Integrity Myopathy), a specific form of exertional...

You will receive the results of the MIM-6 Var.-Test within 3 working days from the time the sample is accepted in the laboratory. Please note the following information when ordering: - Please do not order a separate sample collection set, instead please follow our instructions for hair sample collection: ( link ). - Send the sample to: Generatio GmbH - Center for Animal...

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

PSSM1 is a form of exercise intolerance in which a disorder of the sugar metabolism of the muscles causes muscle damage.
The test detects the mutation (c.926G>A) in the GYS1 gene which causes PSSM1. The inheritance is incomplete autosomal dominant. Horses with one or two copies of the genetic variant (n/P1 or P1/P1) are at risk to develop symptoms of PSSM1; those with two...

Silver results in the decreased storage of the black pigment “eumelanin” in hair, so that horses with black and bay base colors will show a dilution. Horses with a Chestnut base color may be carriers for the Silver mutation but do not develop the diluted coat color themselves. Horses with only one copy of the variant (n/Z) will show the same phenotype as horses with two...

The test determines if the MITF mutation (EquCab3: Chr16:21567245_21567249delGTGTCT) which causes the Splashed White 3 (SW3) phenotype is present. The inheritance is autosomal semi-dominant. SW3 originated in the Quarter Horse "TD Kid".

The test determines if the PAX3 mutation (EquCab3: Chr6:11199140G>C) which causes the Splashed White 4 (SW4) phenotype is present. The inheritance is autosomal semi-dominant. SW4 originated in the Appaloosa Horse "I'za Last Jet".

WFFS is a connective tissue disorder leading to the spontaneous abortion of the fetus or death/humane euthanasia of the foal. The disease is autosomal recessive and the mutation has been found in many breeds including: Warmbloods and related breeds, Riding ponies,Thoroughbreds, Haflingers, Quarter Horses, Paint Horses, and Appaloosas.

The White Spotting W20 variant is found in many breeds. By itself it has very little influence on white patterning; instead, W20 acts as a “booster”: in combination with other “W” mutations, it can greatly increase the amount of white on a horse. It can also boost the amount of white in non-“W” patterns: (eg. Sabino-1, Tobiano, occasionally Frame Overo (when 2 copies are...