Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

This test investigates if the dog carries the mutation in the BEST1 gene that has been described as cause for the disease Canine Multifocal Retinopathy 1 (cmr1) in mastiff-related breeds.The disease is inherited as an autosomal recessive characteristic and only occurs if the dog carries two mutated alleles.

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

Cone-Rod Dystrophy 1, also known as crd1, is a disease in which the cone and rod cells in the retina degenerate, leading to blindness. Clinical signs can be seen as early as 11 weeks of age, and full blindness results in early adulthood.

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: - identification of heterozygous carriers
Genetic testing of the MC1R mutation c.916 C>T will determine whether a dog is a carrier of the predisposition for coat color 'yellow' / 'red'. The trait is inherited in an autosomal recessive manner, two copies of the e allele (genotype e/e) are required to have the characteristic yellow/red coat color.

Application: Carrier identification. Genetic testing of this MC1R variant will determine whether a dog is a carrier of melanistic mask alleles. The trait is inherited in an autosomal dominant manner. A single copy of the Em allele (genotype Em/E) is sufficient to have the characteristic mask.

Application: - Identification of carriers with unclear coat markings.
Dogs with harlequin patterns have a white ground colour and black speckles of different size distributed asymmetrically over the whole body. The prerequisite is the presence of a disposition to merle. If this is the case, the harlequin pattern can be caused by a heterozygous mutation in the PSMB7 gene of...

Application: - Identification of carriers. This test examines whether the dog carries the mutation in the RYR1 gene that has been found to cause malignant hyperthermia (MH). In this disease, problems with the metabolism in the skeletal muscles occur after the administration of certain anaesthetics. This can lead to hyperthermia, heart palpitations, muscle paralysis or organ...

Anwendung: Identifikation der typischen und kryptischen 'Merle'-Anlage. 'Merle' ist eine Farbvariation, die auf Grund der autosomal-dominanten Vererbung bei einer einzelnen Mutation im SILV-Gen auftritt. Voraussetzung ist, dass am E-Lokus eine 'E'-Anlage gegeben ist. Das Ausmaß der Merle-Zeichnung variiert stark. Bei reinerbigen Auftreten sind die Folgen je nach Rasse z.T....