The bundles combines testing for CDPA and CDDY/IVDD type 1.
This combination is of interest to all those who want to look into the two genes known to be involved in short leggedness.
Chondrodysplasia (CDPA)is a genetic disorder characterized by the abnormal growth of bones, particularly the long bones, leading to the short-legged phenotype.
This condition is caused by an...

The package bundles the investigations on various hereditary diseases that may be of importance in dachshunds.

Application:
The bundle covers the DNA tests required by the SDC (Swiss Dachshund Club) for the breeding approval of all varieties of Short- and Long-haired Dachshunds.
DOES NOT INCLUDE DNA IDENTITY DETERMINATION with parentage assessment. Please select 'Sample is already deposited at Generatio' if your animal has been sampled as part of the SDC puppy registration process.

The package includes a selection of tests for hereditary diseases that may be relevant for shorthair dachshunds:
NCL1, NCL2, cord1/crd4-PRA, Colour Dilution Neuropathy (CDN), CDDY/ IVDD

The package includes a selection of tests on coat colors and coat characteristics that can play a role in the breeding selection of dachshunds of all varieties. (Merle, S-Lokus, A-Lokus)

The package covers the tests for A-locus, B-locus and hair length, which might play a role in the breeding selection of dachshunds/dachshunds of all varieties with regard to coat expression

Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

The test identifies the presence of the FGF4 retrogene insertion on chromosome 12. This mutation is one cause of shortened legs (CDDY, disproportional dwarfism) in dogs. It is also a risk factor for the occurrence of Hansen type 1 disc herniation (IVDD type 1). Leg length will differ depending on if the dog has one or two copies of the mutation as the mutation is incomplete...

The hereditary disease, whose causative mutation in the MYO5A gene is detected with the test, was initially called Griscelli type 1 analogue syndrome because of the analogy in humans. In dogs, the term 'Colour Dilution Neuropathy' (CDN) has become common as well.
The mode of inheritance is autosomal recessive. If homozygous, living but non-viable puppies are born....

The test examines whether the FGF4L1 retrogen insertion is present in the chromosome 18 (CFA18) of the investigated dog. This mutation is described as a cause of chondrodysplasia (CDPA) or short-legged phenotype in dogs. The inheritance is autosomal dominant.

Application:
- Identification of heterozygous carriers
The test examines the mutation in the RPGRIP1 gene, which is a risk factor for cone-rod dystrophy 4-progressive retinal atrophy (crd4/cord1-PRA) in longhaired miniature dachshunds.This is a complex disease in which other gene mutations also play an important role in disease progression.