This test investigates if the dog carries the mutation in the BEST1 gene that has been described as cause for the disease Canine Multifocal Retinopathy 1 (cmr1) in mastiff-related breeds.The disease is inherited as an autosomal recessive characteristic and only occurs if the dog carries two mutated alleles.

Cone-Rod Dystrophy 1, also known as crd1, is a disease in which the cone and rod cells in the retina degenerate, leading to blindness. Clinical signs can be seen as early as 11 weeks of age, and full blindness results in early adulthood.

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: - Identification of carriers with unclear coat markings.
Dogs with harlequin patterns have a white ground colour and black speckles of different size distributed asymmetrically over the whole body. The prerequisite is the presence of a disposition to merle. If this is the case, the harlequin pattern can be caused by a heterozygous mutation in the PSMB7 gene of...

Anwendung: Identifikation der typischen und kryptischen 'Merle'-Anlage. 'Merle' ist eine Farbvariation, die auf Grund der autosomal-dominanten Vererbung bei einer einzelnen Mutation im SILV-Gen auftritt. Voraussetzung ist, dass am E-Lokus eine 'E'-Anlage gegeben ist. Das Ausmaß der Merle-Zeichnung variiert stark. Bei reinerbigen Auftreten sind die Folgen je nach Rasse z.T....

Application: - Determination of the predisposition status for breeding planning. - Diagnosis in case of partial white colouring.
This test is used to determine whether the dog carries the hereditary disposition for the piebald pattern. According to Schmutz et al, the SINE insertion tested can be a marker for the piebald allele with an accuracy of at least 95% in those dog...

This package covers all requirements which are necessary for breeding approval by the DRC.
Included are:
1) Sample and data registration
2) Archiving of the EDTA blood sample
3) DNA profile identity (ISAG marker set)