Combo package for the two base colors of horse coat coloring (Agouti, Extension).

Application:
- Clarification of underlying causes in horses symptomatic for Exertional Myopathy
- Pre-purchase examination: assessment of the risk of developing Exertional Myopathy type MIM due to genetic predisposition.
- Mating planning.
The test contains the 6 gene variants P2, P3, P4, P8, Px, K1, which are important genetic predispositions for the development of MIM =...

ACAN-dwarfism is found in Shetland ponies and miniature horses, in which abnormal cartilage growth leading to skeletal problems and dwarfism. Four different disease-causing variants of the ACAN gene are known so far: d1, d2, d3* and d4. The inheritance is autosomal recessive.

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

Horses with one or two copies of the Champagne mutation will have diluted coat color, including mane and tail. Classic Champagne (black base color), Gold Champagne (chestnut base color), Amber Champagne (bay base color) are possible.

The Cream mutation dilutes the red pigment (phaeomelanin) in the hair. It is incomplete dominant: one copy of the cream dilution (n/Cr) results in Palomino and Buckskin coat colors; Smoky Black (black carrying cream) horses look the same as normal black. With two copies of the Cream variant (Cr/Cr), the dilution effect is complete, giving the Cremello, Perlino, and Smoky...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

HWSD is a disorder where the layers of the hoof do not hold together correctly. Affected horses can have an unstabile, brittle hoof wall, leading to inflammation of the hooves and hoof pain. The disorder is autosomal recessive.

In the course of this examination, Generatio establishes the SNP markers, which, as DNA fingerprints, ensure the identity of a horse and, when compared in parentage assessments, show whether a parentage statement is correct. As a result, you will receive a DNA identity card in PDF format for each animal. To use SNP ID profiles in parentage assessments, all animals involved...

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

The KIT Noriker roan allele has been found in Noriker, Lipizzan, Quarter Horse, Murgese and some draft breeds. It is not the classical roan mutation found in most roan quarter horses, but it has not yet been tested in a wide variety of breeds.

PATN1 is a modifier of the Leopard Spotting Complex. If a horse has Pattern-1 and LP, the foal will show an increased amount of white on its body (often more than 60%). If a horse has Pattern-1 without LP, there is no phenotypic effect on the coat color.