Combo package for the two base colors of horse coat coloring (Agouti, Extension).

Application: - Clarification of underlying causes in horses symptomatic for Exertional Myopathy - Pre-purchase examination: assessment of the risk of developing Exertional Myopathy type MIM due to genetic predisposition. - Mating planning. The test includes 6 gene variants P2, P3, P4, P8, Px, K1, which are important genetic predispositions for the development of MIM = Muscle...

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

Cerebellar Abiotrophy is an autosomal recessive disease where affected animals develop ataxia due to the progressive death of brain cells responsible for movement. It is found in Arabians and related breeds.

In the course of this examination, Generatio establishes the SNP markers, which, as DNA fingerprints, ensure the identity of a horse and, when compared in parentage assessments, show whether a parentage statement is correct. As a result, you will receive a DNA identity card in PDF format for each animal. To use SNP ID profiles in parentage assessments, all animals involved...

Dun is the original coat color of all horses (wild-type). Over time, two mutations (nd1 and nd2) caused the now wide-spread undiluted phenotypes most modern horses display. Horses with one or two copies of this variant (D/D, D/nd1, D/nd2) are Dun and show the diluted coat color and the primitive markings (zebra stripes, dorsal stripe) on their legs and back. A dun horse must...

Turner syndrome is the most common chromosomal abnormality in mares.
The missing X chromosome leads to an incomplete internal reproductive tract with a normal exterior phenotype.
Application of the test:
- Differential diagnosis of infertility, inactive ovaries and underdeveloped fallopian tubes
- Ensuring normal X-chromosomal constitution in mares that are not jet sexually...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

The KIT Noriker roan allele has been found in Noriker, Lipizzan, Quarter Horse, Murgese and some draft breeds. It is not the classical roan mutation found in most roan quarter horses, but it has not yet been tested in a wide variety of breeds.

Testing for Sabino 1 allows breeders to identify:
- homozygous animals (animals with two copies of the variant) which will always produce foals with the Sabino 1 pattern.
- if a given white spotting pattern is based on the Sabino 1 variant.

Application:
- Identification of healthy carrier animals (N/scid)
- Confirmation of the wild-type genotype (N/N)
- Differential diagnosis in cases of clinical immunodeficiency
The test reliably detects the presence of the mutation, thereby enabling safe breeding planning with carrier animals.
Offspring with two copies of the SCID mutation would be affected by ‘severe...