Combo package for the two base colors of horse coat coloring (Agouti, Extension).

Application: - Clarification of underlying causes in symptomatic horses - Predisposition assessment in the context of a pre-purchase examination - Mating planning. The MIM-6 variant test replaces the name 'PSSM2 test' to reflect the effects of the tested variants and their significance for exertional myopathies. The test still contains the 6 gene variants P2, P3, P4, P8, Px,...

You will receive the results of the MIM-6 Var.-Test within 5 working days from the time the sample is accepted in the laboratory. Please note the guidelines below when ordering: - Please do not order a separate sampling set , instead please follow our instructions for hair sample collection: Link . - Send the sample to: Generatio GmbH - Center for Animal Genetics |...

Leopard Complex Spotting (LP) and Pattern-1 work together to influence the phenotype and amount of white in horses with the LP complex.

The Agouti gene (A) is involved with the production of both red (pheomelanin) and black (eumelanin) pigments. It regulates the relative amounts of each pigment produced in melanocytes (pigment-producing cells) in different regions of the horse’s body. A functional version (AA or Ae) results in a horse that has a base color of bay with black mane, tail, legs and ear tips. Two...

The Cream mutation dilutes the red pigment (phaeomelanin) in the hair. It is incomplete dominant: one copy of the cream dilution (n/Cr) results in Palomino and Buckskin coat colors; Smoky Black (black carrying cream) horses look the same as normal black. With two copies of the Cream variant (Cr/Cr), the dilution effect is complete, giving the Cremello, Perlino, and Smoky...

Horses with two copies of the MC1R variant (ee) are chestnut (red, sorrel) in color. Horses with only one copy of this variant (Ee) are bay or black-based (depending upon their variants at the Agouti locus), but carry chestnut. A horse that does not carry the variant (EE) cannot have a chestnut foal, even if bred to a chestnut horse.

The test detects the mutation in the STX17 gene (a 4.6 kb intronic duplication) which is causative for the Grey coat color. It is also a risk factor for melanoma. The inheritance is autosomal dominant. Horses with one or two copies of the genetic variant (n/G or G/G) will grey with time. This test detects if a horse has one or two copies of the Grey mutation.

Leopard Complex Spotting (LP) produces characteristic traits including white stripes on hooves, visible white sclera in eyes, speckled/mottled skin around the eyes, muzzle and genital regions, and progressive “varnish roan” coat color. Alone, (LP) may only show these characteristics on an otherwise solid-colored horse. Other genetic variants interact with LP; the Pattern-1...

Malignant Hyperthermia is an autosomal dominant mutation where fever, muscle rigidity and respiratory distress and even death can be triggered by specific anaesthetics or other stress/exercise. It also worsens the symptoms of horses with PSSM1 and 2.

PATN1 is a modifier of the Leopard Spotting Complex. If a horse has Pattern-1 and LP, the foal will show an increased amount of white on its body (often more than 60%). If a horse has Pattern-1 without LP, there is no phenotypic effect on the coat color.

PSSM1 is a form of exercise intolerance in which a disorder of the sugar metabolism of the muscles causes muscle damage.
The test detects the mutation (c.926G>A) in the GYS1 gene which causes PSSM1. The inheritance is incomplete autosomal dominant. Horses with one or two copies of the genetic variant (n/P1 or P1/P1) are at risk to develop symptoms of PSSM1; those with two...