Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

Application: Identification of carriers for straight coat.
In most dog breeds curly hair is caused by a mutation in the KRT71 gene. A single defect is sufficient representing a dominant autosomal mode of inheritance. This mode allows for carriers with hidden non-curly alleles. Mating of a carrier dam with a carrier sire will result in 25% non-curly offspring. Long hair...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: - identification of heterozygous carriers
Genetic testing of the MC1R mutation c.916 C>T will determine whether a dog is a carrier of the predisposition for coat color 'yellow' / 'red'. The trait is inherited in an autosomal recessive manner, two copies of the e allele (genotype e/e) are required to have the characteristic yellow/red coat color.

Application: Carrier identification. Genetic testing of this MC1R variant will determine whether a dog is a carrier of melanistic mask alleles. The trait is inherited in an autosomal dominant manner. A single copy of the Em allele (genotype Em/E) is sufficient to have the characteristic mask.

Application: - Identification of carriers with unclear coat markings.
Dogs with harlequin patterns have a white ground colour and black speckles of different size distributed asymmetrically over the whole body. The prerequisite is the presence of a disposition to merle. If this is the case, the harlequin pattern can be caused by a heterozygous mutation in the PSMB7 gene of...

Application of the test:
(a) identification of carrier animals from a mating of carrier x free animal. b) Differential diagnosis in urinary stones and inflammation of the urogenital tract.
It is investigated whether the dog carries the mutation in the gene SLC2A9, which has been described as a cause of hyperuricosuria. Hyperuricosuria is the presence of excessive amounts of...

Application:
- Identification of predisposition K(B). This test examines whether the dog carries the dominant K(B) allele. If this is present, the animal has a solid black coat in the pigmented areas and the effect of the A-locus is not observed. If the animal has the genotype 'b/b' at the B-locus, the coat colour would not be black, but brown. The effect of the genotype at...

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.

Application: - Identification of carriers. This test examines whether the dog carries the mutation in the RYR1 gene that has been found to cause malignant hyperthermia (MH). In this disease, problems with the metabolism in the skeletal muscles occur after the administration of certain anaesthetics. This can lead to hyperthermia, heart palpitations, muscle paralysis or organ...