The bundle combines various tests on hereditary diseases and coat colors that may be important in dogs of the breed 'Labrador Retriever'.
All examinations are carried out at generatio.

The package bundles the tests for hereditary diseases that may be important for the breeding approval in the DRC.
Included: SD2, CNM, prcd-PRA***, EIC***, HNPK*** (*** = partner laboratory, app. 4-5 weeks turn-around-time)

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: - identification of heterozygous carriers
Genetic testing of the MC1R mutation c.916 C>T will determine whether a dog is a carrier of the predisposition for coat color 'yellow' / 'red'. The trait is inherited in an autosomal recessive manner, two copies of the e allele (genotype e/e) are required to have the characteristic yellow/red coat color.

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application of the test:
- Identification of heterozygous, healthy carriers for breeding selection.
- Differential diagnosis of weakness of the backhand
The test determines whether the mutation in the DNM1 gene is present, which has been described as a risk factor for the occurrence of 'Exercise Induced...

PLEASE NOTE: the mandatory material is a min. of 2 ml EDTA-blood
Application of the test:
- Recognition of mixed-breed, healthy carriers for breeding selection
- Differential diagnosis of nose/nostrils with scaling.
HNPK, Hereditary Nasal Parakeratosis, is a more or less pronounced desquamation of the nose observed in Labrador Retrievers.
The skin that has been damaged in...

Application of the test:
(a) identification of carrier animals from a mating of carrier x free animal. b) Differential diagnosis in urinary stones and inflammation of the urogenital tract.
It is investigated whether the dog carries the mutation in the gene SLC2A9, which has been described as a cause of hyperuricosuria. Hyperuricosuria is the presence of excessive amounts of...

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.