The bundle combines various tests on hereditary diseases and coat colors that may be important in dogs of the breed 'Labrador Retriever'.
All examinations are carried out at generatio.

The package bundles the tests for hereditary diseases that may be important for the breeding approval in the DRC.
Included: SD2, CNM, prcd-PRA***, EIC***, HNPK*** (*** = partner laboratory, app. 4-5 weeks turn-around-time)

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

This test investigates if the dog carries the mutation in the BEST1 gene that has been described as cause for the disease Canine Multifocal Retinopathy 1 (cmr1) in mastiff-related breeds.The disease is inherited as an autosomal recessive characteristic and only occurs if the dog carries two mutated alleles.

Application: a) Carrier identification in offspring after mating of a 'CNM-carrier' with a 'CNM-free' animal, b) Differential diagnosis in cases of clinical muscle insufficiency. Centronuclear Myopathy (CNM), also described as HMLR, or Hereditary Myopathy of Labrador Retrievers, has an autosomal recessive expression. Affected animals show insufficient muscle function...

Cone-Rod Dystrophy 1, also known as crd1, is a disease in which the cone and rod cells in the retina degenerate, leading to blindness. Clinical signs can be seen as early as 11 weeks of age, and full blindness results in early adulthood.

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: - identification of heterozygous carriers
Genetic testing of the MC1R mutation c.916 C>T will determine whether a dog is a carrier of the predisposition for coat color 'yellow' / 'red'. The trait is inherited in an autosomal recessive manner, two copies of the e allele (genotype e/e) are required to have the characteristic yellow/red coat color.

Application of the test:
- Identification of heterozygous, healthy carriers for breeding selection.
- Differential diagnosis of weakness of the backhand
The test determines whether the mutation in the DNM1 gene is present, which has been described as a risk factor for the occurrence of 'Exercise Induced Collapse', EIC. The inheritance is autosomal recessive, so that both...

Application of the test:
- Recognition of mixed-breed, healthy carriers for breeding selection
- Differential diagnosis of nose/nostrils with scaling.
HNPK, Hereditary Nasal Parakeratosis, is a more or less pronounced desquamation of the nose observed in Labrador Retrievers.
The skin that has been damaged in this way can be more easily infected by pathogens, which can lead...