Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application: Carrier identification. Genetic testing of this MC1R variant will determine whether a dog is a carrier of melanistic mask alleles. The trait is inherited in an autosomal dominant manner. A single copy of the Em allele (genotype Em/E) is sufficient to have the characteristic mask.

Application of the test:
(a) identification of carrier animals from a mating of carrier x free animal. b) Differential diagnosis in urinary stones and inflammation of the urogenital tract.
It is investigated whether the dog carries the mutation in the gene SLC2A9, which has been described as a cause of hyperuricosuria. Hyperuricosuria is the presence of excessive amounts of...

Application:
- Identification of predisposition K(B). This test examines whether the dog carries the dominant K(B) allele. If this is present, the animal has a solid black coat in the pigmented areas and the effect of the A-locus is not observed. If the animal has the genotype 'b/b' at the B-locus, the coat colour would not be black, but brown. The effect of the genotype at...

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.

Application: - Identification of carriers. This test examines whether the dog carries the mutation in the RYR1 gene that has been found to cause malignant hyperthermia (MH). In this disease, problems with the metabolism in the skeletal muscles occur after the administration of certain anaesthetics. This can lead to hyperthermia, heart palpitations, muscle paralysis or organ...

Application:
- Identification of heterozygous carriers
- Differential diagnosis of coagulation disorders
Von Willebrand disease (vWD) type 1 is due to a reduction of the blood clotting factor of the same name, caused by a mutation in exon 43. The mode of inheritance is autosomal recessive, only dogs with two defective genes are affected. The effect manifests itself in...

This package realizes the minimal prerequisites (archive sample + DNA identity), which are required on behalf of the DRC for breeding approval of all Retriever breeds managed by DRC (exempt Flat Coated Retrievers). Included are: - Sample and data registration
- Archiving of the EDTA blood sample - DNA profile identity (ISAG2006 marker set)