Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

The test detects the mutation (c.643_644dup) in the EFNB3 gene that causes Congenital Mirror Movement Disorder 1 (CMM1). The inheritance is autosomal recessive, meaning that only animals carrying two copies of the mutated gene will be affected. Affected dogs can exhibit varying degrees of limb paralysis and a characteristic gait characterized by synchronous movements of both...

Application: Identification of carriers for straight coat.
In most dog breeds curly hair is caused by a mutation in the KRT71 gene. A single defect is sufficient representing a dominant autosomal mode of inheritance. This mode allows for carriers with hidden non-curly alleles. Mating of a carrier dam with a carrier sire will result in 25% non-curly offspring. Long hair...

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)
Please note: This DNA profile is not a breed determination.

Application: - identification of heterozygous carriers
Genetic testing of the MC1R mutation c.916 C>T will determine whether a dog is a carrier of the predisposition for coat color 'yellow' / 'red'. The trait is inherited in an autosomal recessive manner, two copies of the e allele (genotype e/e) are required to have the characteristic yellow/red coat color.

Application: Carrier identification. Genetic testing of this MC1R variant will determine whether a dog is a carrier of melanistic mask alleles. The trait is inherited in an autosomal dominant manner. A single copy of the Em allele (genotype Em/E) is sufficient to have the characteristic mask.

Application: - Identification of heterozygous carriers.
'Furnishings' are the long eyebrows and whiskers of wire-haired dogs. The predisposition is autosomal-dominant, so that only by testing can it be determined whether a phenotypically wire-haired animal is homozygous or heterozygous for 'Furnishings' and the wire-haired coat texture. Knowing the predisposition to...

Application:
- Identification of predisposition K(B). This test examines whether the dog carries the dominant K(B) allele. If this is present, the animal has a solid black coat in the pigmented areas and the effect of the A-locus is not observed. If the animal has the genotype 'b/b' at the B-locus, the coat colour would not be black, but brown. The effect of the genotype at...

Application.:
- Identification of carriers for long hair in short-haired dogs. - Proof of long-hair predisposition in cases of unclear phenotype.
Long hair is inherited in an autosomal recessive fashion, meaning that two copies (status L/L) of the long hair variant are required to produce long hair. Dogs with one copy (K/L) or no copies (K/K) will have short hair.

Application: - Identification of the effective and cryptic “Merle” variant. Merle” is a colour variation that occurs due to a mutation in the PMEL17/SILV gene. A prerequisite is that an “E” gene is present at the E locus. The variation is variable in extent and only develops its typical effect above a certain threshold value. Shorter variants do not appear and are considered...

Application:
- Identification of heterozygous carriers
- Differential diagnosis of coagulation disorders
Von Willebrand disease (vWD) type 1 is due to a reduction of the blood clotting factor of the same name, caused by a mutation in exon 43. The mode of inheritance is autosomal recessive, only dogs with two defective genes are affected. The effect manifests itself in...