The test detects the mutation (c.643_644dup) in the EFNB3 gene that causes Congenital Mirror Movement Disorder 1 (CMM1). The inheritance is autosomal recessive, meaning that only animals carrying two copies of the mutated gene will be affected. Affected dogs can exhibit varying degrees of limb paralysis and a characteristic gait characterized by synchronous movements of both...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)
Please note: This DNA profile is not a breed determination.

Application of the test:
(a) identification of carrier animals from a mating of carrier x free animal. b) Differential diagnosis in urinary stones and inflammation of the urogenital tract.
It is investigated whether the dog carries the mutation in the gene SLC2A9, which has been described as a cause of hyperuricosuria. Hyperuricosuria is the presence of excessive amounts of...

Application: - Identification of carriers. This test examines whether the dog carries the mutation in the RYR1 gene that has been found to cause malignant hyperthermia (MH). In this disease, problems with the metabolism in the skeletal muscles occur after the administration of certain anaesthetics. This can lead to hyperthermia, heart palpitations, muscle paralysis or organ...

The test determines the genome-based values for individual inbreeding and diversity values. Applications: - Clarification of an individual's inbreeding status in cases of unspecified general health issues. - Development of a genome-based mating planning scheme for the preservation or improvement of genetic diversity in a breeding population. Generatio determines all 3...

The combination provides the DNA profile 'Identity' of the ISAG2020 marker set (SNP markers) supplemented by an evaluation of the individual parameters for 'Inbreeding & Fitness' (genomic inbreeding coefficient, g-IK | extent of heterozygosity, HE value | ROH profile = size and position of the inbred regions on the chromosomes)
The analyses are based on SNP array analysis...