The package bundles the 3 most commonly used DNA tests for predispositions that are of importance in dogs of the 'Doberman' breed: vWD, B-Locus, D-Locus

The package bundles vWD, B-Locus, D-Locus, Narcolepsy and Malignant Hyperthermia, covering DNA tests that may be relevant to dogs of the 'Doberman' breed.

Application: Identification of hidden alleles in breeds that show A-locus dependent variation in coat colors. The four A-Locus alleles are expressed as a hierarchy: a(y) > a(w) > a(t) > a. A- locus predispositions only take effect if there is no „K(B)“-allele at the K-Locus and at least one „E“-allele at the E-Locus. Other loci (B-Locus, D-Locus) may also influence A-Locus...

Application: Testing coat color 'brown' identifies animals that carry „b“-alleles. The brown coat color can develop if both genes are 'affected' (b/b) and an „E“-Allel at the E-locus is present. Effective Ay and Aw alleles at the A-locus may hide a b/b situation. 3 loci are analysed.

Application: - Carrier identification. Coat color dilution is autosomal-recessive. Dilution manifests if the mutation is homozygous (d/d). A dog with two variant copies of the MLPH gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color genes present in the individual. In some breeds dilute coat color can be associated with...

This DNA-profile identity contains additional markers for increased reliability in parentage testing and especially for determining genetic diversity.
IT IS NOT REQUIRED IN THIS FORM BY ANY BREEDING COMPANY - the basic ISAG marker set is sufficient (article GDI100)

With this ID-profile a requirement for breeding approval at various breeding clubs in Germany but also abroad is fulfilled (see DNA-programs, e.g. DTK, DNK, DRC, VND or KZG). The set is internationally distributed and consists of the 22 recommended markers.
The result is issued as an ATC certificate identity with electronic signature and can be securely communicated over the...

Application of the test:
(a) identification of carrier animals from a mating of carrier x free animal. b) Differential diagnosis in urinary stones and inflammation of the urogenital tract.
It is investigated whether the dog carries the mutation in the gene SLC2A9, which has been described as a cause of hyperuricosuria. Hyperuricosuria is the presence of excessive amounts of...

Application: - Identification of carriers. This test examines whether the dog carries the mutation in the RYR1 gene that has been found to cause malignant hyperthermia (MH). In this disease, problems with the metabolism in the skeletal muscles occur after the administration of certain anaesthetics. This can lead to hyperthermia, heart palpitations, muscle paralysis or organ...

Application: - Identification of heterozyous carriers. This test is used to determine whether the dog carries the mutation in the HCRTR2 gene that has been found to cause narcolepsy in Doberman Pinschers. The most striking feature of this disease is the triggering of cataplexy by excitatory events. This leads to flaccid paralysis of individual muscle groups (partial...

Application:
- Identification of heterozygous carriers
- Differential diagnosis of coagulation disorders
Von Willebrand disease (vWD) type 1 is due to a reduction of the blood clotting factor of the same name, caused by a mutation in exon 43. The mode of inheritance is autosomal recessive, only dogs with two defective genes are affected. The effect manifests itself in...

In addition to the DNA tests of the 'basic test package for predispositions', an ID profile with the ISAG marker set will be created.
This ISAG ID certificate is requested by some international breeding organizations for 'Dobermans' from the DNA program of the Dobermann Verein.